Cisplatin hearing loss data

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August undefined, 2024

WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … WebTaking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors,

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WebModern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that … WebAfter the first cycle of cisplatin, in the placebo ears, 76% of patients experienced hearing loss in the clinical frequency range that met the ototoxicity criteria established by the American Speech-Language-Hearing Association. dialect and diction

Hearing Loss: An Under-Recognized Side Effect of Cancer …

WebSigns and symptoms seen in children as ototoxicity develops include: High-frequency (≥4 kHz) sensorineural hearing loss that is bilateral (affecting both sides), progressive, and … WebFeb 24, 2024 · Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of … WebPrimary Endpoint: The primary endpoint is the change in hearing sensitivity as measured by pure-tone audiometry between the pre-treatment (before cisplatin-based CRT) hearing … dialect and accent examples

Long After Chemotherapy, Cisplatin and Hearing Loss Remain

Mechanisms of Aminoglycoside- and Cisplatin-Induced …

http://mdedge.ma1.medscape.com/fedprac/article/227870/oncology/improving-ototoxicity-monitoring-cisplatin-therapy-va-northeast-ohio WebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing loss may result from damage caused by the accumulation of cisplatin in the inner ear. dialect and idiolectWebAug 31, 2016 · Ototoxicity poses a major problem to the cancer patient, as the quality of life after receiving cisplatin chemotherapy may be negatively affected due to hearing loss, resulting in social, emotional, and vocational difficulties, as effective communication is … cinnamon tree diabetic

"WebFeb 12, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not … " - Cisplatin hearing loss data

Cisplatin hearing loss data

Atorvastatin is associated with reduced cisplatin-induced …

WebJan 1, 2024 · The benefits of atorvastatin to the incidence of a CTCAE-defined hearing loss were generally consistent across all subgroups (Figure 3). Overall, 48.8% (156 of 320) of … WebJan 26, 2024 · But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant …

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WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … WebFeb 15, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not all treatment schedules came with the same risk.

WebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs ( Spankovich et al., 2016 ). In an alternative rodent experiment, the otoprotective effect of hypothermia applied through a custom-made cooling device was evaluated in a cochlea implantation situation. WebFeb 11, 2024 · Cisplatin-induced hearing loss (CIHL) is a debilitating toxicity commonly experienced by patients who received cisplatin …

WebSep 21, 2016 · Individually, children in this series first showed decreases in hearing after cumulative cisplatin doses ranging between 75 and 600 mg/m 2 and carboplatin doses between 800 and 3,420 mg/m 2. Patients treated for germ cell tumors (Children's Oncology Group 8882) received the highest cumulative doses of cisplatin. WebSep 1, 2024 · Improving Ototoxicity Monitoring with Cisplatin Therapy at VA Northeast Ohio Healthcare System (VANOHS), An Interdisciplinary Team Approach. Publish date: September 1, 2024. Author(s): Lisa Arfons, MD Yasmine Ayoub, PharmD, BCPS Deborah Fox, RN, BSN, MSHS Jill Lagerstedt, MA, CCC-A, Clinical Audiologist

WebCisplatin-induced hearing loss is mainly attributed to oxidative stress, but recent data suggest that inflammation could be the trigger event leading to inner ear cell death through endoplasmic reticulum (ER) stress, autophagy, necroptosis, and then intrinsic apoptosis.

WebJul 13, 2024 · Hearing loss can have significant long-term consequences for children treated for cancer, said Edward Neuwelt, M.D., of Oregon Health & Science University, who helped lead both recent trials. “Around 60% to … dialect and identityWebJul 2, 2024 · Caffeine pre-treatment further reduced wave I and II amplitudes, suggesting worsening of cisplatin-induced hearing loss. The data is plotted as mean ± SEM (n ≥ 6). Asterisks, * p < 0.05 vs.... dialect and culture of ancient scotlandWebCisplatin is an effective chemotherapeutic agent against pediatric cancers; however, ototoxicity is a concern. This study describes the frequency, severity, and clinical course … dialect and register cinnamon tree downendWebMar 15, 2024 · Cisplatin can cause hearing loss in up to 60% of the treated population, leading to significant impact on QoL. Data from a population-based longitudinal study of age-related hearing impairment (N = 2,688) showed that 28% of adults age 53-97 years … cinnamon tree ellistownWebOct 11, 2024 · The incidence of hearing loss in humans after aminoglycoside treatment remains unclear due to variable dose stratification regimens and limited pure-tone testing … cinnamon tree farmWebAfter the cisplatin treatment marked hearing loss were detected, with ABR thresholds increasing to 34.5 ± 16.1 dB, 40.8 ± 16.7 dB, and 43.7 ± 18.2 dB at 8, 16, and 32 kHz, respectively. NS, normal saline; dB, decibel; ABR, auditory brainstem response. 2.2. Auditory Brainstem Response (ABR) dialect and language