Cisplatin ld50 in mice

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WebThe 50% lethal dose (LD50) of cisplatin in S3 cells was 4 x 10 (-5) M after 20 h incubation and 8.5 x 10 (-6) M after 40 h incubation. Outer medullary collecting duct (OMCD) cells were damaged 30% maximally after 20 h incubation with cisplatin, and LD50 in them became 2.5 x 10 (-5) M after 40 h incubation. WebDetermination of LPS LD50 in C57BL/6 mice. The mice were challenged i.p. with different doses of LPS to monitor the survival rates and organ injury to determine the LD50. (a) Mice were...

Cisplatin promotes the expression level of PD-L1 in the

WebDec 21, 2024 · Mice were divided into a control group, cisplatin-treated group, and cisplatin + myo-inositol-treated group, which were treated with cisplatin or myo-inositol accordingly. Mice received intraperitoneal injection of cisplatin at a dose of 25 mg/kg, and they were sacrificed by cervical dislocation three days later. WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). greene construction services

Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate ...

WebSep 1, 2024 · The serum of nutlin-3a or cisplatin-treated mice was obtained 4 h after LPS injection. Tissues of nutlin-3a or cisplatin-treated mice were obtained 12 h after LPS injection. Survival of mice was monitored after an i.p. injection of LPS (60 mg/kg) or E. coli (1 × 10 8 CFU). WebJun 12, 2024 · Effects of cisplatin (3.5 mg/kg at 72‐h intervals) on UM‐SCC‐22A (A) versus UM‐SCC‐47 (B)‐derived xenograft tumors grown in the flanks of SCID mice were measured at days 0 and 14 (n = 5–8 mice/group, and *P < 0.05 by unpaired Student's t‐test).After the measurement of tumor volumes, CerS1‐6 mRNAs were measured in extracted tumor … WebDec 1, 1987 · Calculated pharmacokinetic parameters (peak concentrations, half-lives, areas under the curve) were compared with the corresponding values in patients at the maximal tolerated dose. Peak plasma concentrations were 2.4- to 20-fold higher in mice than in humans. Initial and terminal half-lives in mice were up to 6 times shorter than in … fluctuating hearing distortion

Cisplatin-Induced Rodent Model of Kidney Injury

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

WebMar 15, 2016 · Cisplatin at 25 mg/kg in PBS (200 μl/animal) was administered by an intraperitoneal injection. Seventy-two hours after cisplatin injection, these mice were euthanized. Another cohort of mice received either 7 or 9 mg/kg cisplatin administered by an intraperitoneal injection once a week for 4 wk. WebDec 23, 2024 · In humans, the volume of peritoneal fluid ranges from 50 to 75 ml ( 7 ), whereas in mice its volume ranges between 0.02 and 0.1 ml ( 8 ). In addition, the peritoneal fluid contains leukocytes and antibodies to fight off infections, and plasma proteins at concentration that is about 50% of what is found in plasma ( 9 ). greene consulting cfp loginWebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 3 of 7 Version: 1.1 7. HANDLING AND STORAGE ... Rat Oral LD50 3000 mg/kg Sodium chloride Eye Irritation Rabbit Moderate Mouse Oral LD 50 4000 mg/kg Mouse Oral LD 50 32.7 mg/kg ... fluctuating heart rate while sitting

"WebMay 1, 1996 · However, when a dose equal to one-half of the LD50 was administered in each solution to mice with i.p. tumours, survival of mice given the CDDP in hypotonic solution was significantly... " - Cisplatin ld50 in mice

Cisplatin ld50 in mice

Induction of apoptosis in leukemia cell lines by new copper(II

WebOct 6, 2014 · Synonyms Cisplatin; cis-DDP Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product use. Details of the supplier of the safety data sheet Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / … WebHowever, the immune tolerance limits the effect of chemotherapeutic drugs. Therefore, the mechanism of cisplatin in promoting PD-L1 expression by YAP1 was investigated in the present study, and we found that cisplatin increased the expression level of YAP1 in the mouse liver with H22 cells.

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WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Trade Name: Platamine; Cisplatino; Cisplatine; Platiblastin; Plastisil; Platiblastin S Chemical Family: Mixture Intended Use: Pharmaceutical product used as Antineoplastic 2. COMPOSITION/INFORMATION … WebMouse IP LD50 40 mg/kg No data available. Material Name: Cisplatin Injection Sodium chloride Molecular Formula: Rat Oral LD50 3000 mg/kg Mixture Mouse Oral LD50 4000 mg/kg Version: 1.0 Cisplatin Mannitol Molecular Weight: Rat Oral LD 50 13500 mg/kg Mixture Rat Oral LD 50 25.8 mg/kg

WebCisplatin was positive in a battery of in vitro and in vivo genotoxicity assays to detect mutagenic and clastogenic activity. Carcinogenicity Cisplatin has been shown to be carcinogenic in mice and rats. Secondary malignancies have been reported in cancer … WebMouse IP LD50 40 mg/kg No data available. Material Name: Cisplatin Injection Sodium chloride Molecular Formula: Rat Oral LD50 3000 mg/kg Mixture Mouse Oral LD50 4000 mg/kg Version: 1.0 Cisplatin Mannitol Molecular Weight: Rat Oral LD 50 13500 mg/kg …

WebCisplatin is rapidly and well absorbed systemically following intraperitoneal administration, resulting in 50-100% of the degree of systemic exposure compared with intravenous administration when comparable doses are given (McEvoy, 1995). 8.7.2 Distribution by route of exposure After intravenous administration cisplatin disappears from the plasma … WebThe LD 50 was 8.6 mg/kg for free cisplatin and 103.4 mg/kg for cisplatin-loaded nanoparticles, as shown in Table 3. Therefore, compared with free cisplatin, the nanopar- ticles loaded with...

WebOct 1, 2024 · In addition, significant immune cell infiltration was observed in the kidney after four doses of 9 mg/kg cisplatin, contrary to what has been previously reported. These results indicate that multiple strains of mice can be used with our repeated low-dose …

Webcisplatin can be used to cause renal dysfunction as an approach to mimic human serum levels of renally excreted drugs. We aimed to determine the dose of cisplatin that did not affect the survival rate of mice and to achieve human-like serum concentrations of … fluctuating home loanWebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … fluctuating hormonesWebAug 6, 2024 · The mice in cisplatin groups were intraperitoneally administered (2 mg/kg cisplatin dissolved in 0.9% saline) with 0.1 ml of cisplatin. The mice in the normal control (NC) group were intraperitoneally injected with physiological saline. The … greene construction massWebProtocol (AUP). The MSDS must be attached to the AUP. 5.2. General precautions: 5.2.1. Pregnant or breast -feeding women should not work with cisplatin. 5.2.2. The following personal protective equipment mu st be worn at all times when handling cisplatin (in addition to the personal protective requirements of the animal room): 5.2.2.1. greene consulting groupWebApr 25, 2014 · Cisplatin (dichlorodiamino platinum) is an inorganic platinum-based chemotherapeutic agent that is widely used in the treatment of a variety of solid malignant tumors such as head and neck, lung, testis, ovarian, and bladder cancers [9]. fluctuating hormone levelsWebAug 14, 2024 · The vehicle control mice were injected with normal saline (cisplatin group) or corn oil (AAI group). After collecting the blood and urine samples from each mouse, the levels of nephrotoxic... greene consulting cfp reviewsWebThese human neoplastic cells are also more susceptible than peripheral blood mononuclear cells (PBMCs) toward the tested compounds. Using C57BL/6 mice an LD50 of 55mgkg(-1) was determined for complex (2), suggesting that this compound is almost four times less toxic than cisplatin (LD50=14.5mgkg(-1)). greene contracting services inc