Cytochrome bd and stress responses
WebJul 1, 2014 · Cytochrome bd is a respiratory oxidase found in many bacterial pathogens. • Members of the bd-family were shown to promote bacterial virulence. • Cytochrome bd … WebJan 7, 2012 · To investigate the regulation of respiratory genes and function of electron transport branches in Z. mobilis, several mutants of the common wild-type strain Zm6 (ATCC 29191) were constructed and analyzed. Mutant strains with a chloramphenicol-resistance determinant inserted in the genes encoding the cytochrome b subunit of the …
Cytochrome bd and stress responses
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WebGrowing evidence supports the hypothesis that bd-type oxidases contribute to bacterial virulence by promoting microbial survival under oxidative and nitrosative stress conditions. For these reasons, cytochrome bd represents a protein target for the development of next-generation antimicrobials. Publication types Research Support, Non-U.S. Gov't WebMar 15, 2024 · Cytochrome bd is a triheme copper-free terminal oxidase in membrane respiratory chains of prokaryotes. This unique molecular machine couples electron transfer from quinol to O2 with the generation …
WebAug 10, 2024 · All these results showed that Cytbd is negatively regulated by CydE and derepressed by sulfate. In addition, Cytbd contributes to the resistance of sulfate and sulfide, and sulfide could be used as a … WebMay 1, 2024 · The most obvious function of cytochrome bd is compensation for chemical inhibition of the parallel cytochrome bcc/aa 3 branch of the mycobacterial respiratory chain (Fig. 1).However, various studies suggest an important role also in the defense against inhibitors of ATP synthase, NADH dehydrogenase effectors and menaquinone …
WebOct 21, 2016 · The cytochrome bd-I complex, encoded by the cydABXoperon, is expressed maximally in microaerobic environments under the dual control of the transcription factors ArcA and FNR22,23, and is up-regulated in response to NO20. WebJun 1, 2024 · Horizontal gene transfer (HGT) has been well documented as a driving force in the evolution of bacteria. It has been shown that a horizontally acquired gene, xoc_2868, involved in the global response against oxidative stress and pathogenicity of Xanthomonas oryzae pv.oryzicola strain BLS256. However, as a transcriptional factor (TF), the …
WebDec 20, 2016 · Collectively, our investigations indicate that cytochrome bd is a critical means by which Salmonella resists the nitrosative stress that is engendered in the innate response of mammalian hosts while it concomitantly allows for proper O2 utilization in …
WebJul 1, 2014 · It can be concluded that cytochrome bd, although not required for aerobic growth, plays an important role in response to antibacterial stress and appears highly … how to replace chain on ryobi chainsawWebMay 10, 2024 · Cytochrome bd displays a unique binding domain for the oxidation of quinol. (A) Ribbon model of G. thermodenitrificans bd oxidase with aurachin D bound (slate sticks). (B) Detailed representation of the … north avs limitedWebJul 30, 2024 · Since cytochrome bd is a key enzyme for the survival of prokaryotes and is absent in mammals, it is a promising therapeutic target for the development of … north awardsWebSep 8, 2024 · The CydDC complex is involved in the assembly of cytochrome bd-I, a terminal oxidase of the respiratory chain required for growth under low oxygen conditions.It has been suggested that CydDC shuttles excessive l-cysteine from the cytoplasm to the periplasm, thereby maintaining bacterial redox homeostasis.Here, we demonstrate that … northaw cofe primary schoolWebAug 3, 2011 · The results from these studies are reviewed here in the light of the proposal that physiologically cytochrome bd can enhance bacterial tolerance to nitrosative stress, thereby promoting pathogenicity. 2 … how to replace chain on husqvarna chainsawWebDec 21, 2008 · Our experiments suggest that the upregulation of cytochrome bd seen in gene expression patterns is probably due to cytochrome bd conferring resistance to NO stress when compared with... northaw community orchardWebNov 1, 2011 · Cytochrome bd is a respiratory quinol:O 2 oxidoreductase found in many prokaryotes, including a number of pathogens. The main bioenergetic function of the … northaw church of england