Polyneddylation
WebHere, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates. We also show … Web(biochemistry) Multiple neddylation ... Definition from Wiktionary, the free dictionary
Polyneddylation
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WebSep 24, 2024 · HYPK scaffolds the Nedd8 and LC3 proteins to initiate formation of autophagosome around polyneddylated huntingtin exon1 aggregates Webvirus-associated ubiquitin-specific protease; Polyneddylation; Polyubiquitination; Ubiquitin-specific protease 7 1. Introduction Protein degradation in eukaryotic cells is mediated by either lysosome or proteasome pathway. Lysosome-mediated degra-dation pathway is involved in degradation of 10–20% proteins
WebImmunocytochemistry assay confirmed that USP7 co‑localizes with PP2A in the cytoplasm and nucleus of HeLa cells. Moreover, western blotting and immunoprecipitation were performed to determine whether polyubiquitination and polyneddylation of PP2A were formed. The results of the present study demonstrated that USP7 was a deubiquitinating ... WebAug 1, 2006 · The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). …
WebBecause Myc:AXR1 cannot be efficiently separated from neddylated cullins in anti-NEDD8 immunoblots, we examined Myc:AXR1 abundance and neddylation using anti-Myc immunoblots. There, we found that increases in the NEDD8 gene dosage also led to increased multi- or polyneddylation of AXR1 (Fig. 7D, AXR1-N8 (2×), lane 6). WebNedd8 is a small ubiquitin-like protein that can be conjugated to substrate-proteins in a process known as neddylation. Although neddylation plays a critical regulatory role in cell …
WebJul 31, 2014 · It is reported that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates and that HYPK functions as an autophagy receptor in the polynedylation-dependent aggrephagy. Expand. 4. PDF.
WebNov 26, 2024 · Here, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein … highest rated halloween costume storesWebOct 6, 2024 · Introduction. Neddylation is a revisable post-translational modification by covalently adding a ubiquitin-like molecule neuronal precursor cell-expressed … highest rated hamilton beach kettleWebMay 31, 2011 · Europe PMC is an archive of life sciences journal literature. highest rated hallmark christmas movieWebOct 22, 2024 · The authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregation and protecting the ubiquitin proteasome system. Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like … highest rated hallmark christmas moviesWebDec 29, 2014 · It is well-accepted that the length and linkage types of the ubiquitin chain on a given substrate dictate the fate of the ubiquitinated proteins. In contrast, the biological … how has animal testing helped scienceWebMay 1, 2012 · Supporting the existence of polyneddylation, high-molecular-weight NED-Am J Cardiovasc Dis 2014;4(4):140-158 D8-immunoreactive species were often observed when affinity purification of NEDD8 ... highest rated handheld gameWebFeb 5, 2008 · In contrast, multiple lysines of p53 and EGFR seem to be involved in neddylation. 16, 18 Interestingly, in vitro neddylation of Cul-1 resulted in hyperneddylation by immunoblotting analysis, 19 although it is not known whether the hyperneddylation of Cul-1 is due to the formation of multiple mononeddylation or polyneddylation on Cul-1. highest rated handguns 2015